2d fighter maker 2002 v1 02712/31/2022 ![]() ![]() An understanding of these changes is crucial for a correct interpretation of in vitro data. HNF-4α), resulting in up- and downregulation of hundreds of genes. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4α, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. ![]() Thasler, 47 Tamara Vanhaecke, 14 Mathieu Vinken, 14 Thomas S. Stelzer, 22 Bruno Stieger, 9 Regina Stöber, 1 Yuichi Sugiyama, 17 Ciro Tetta, 19 Wolfgang E. ![]() Przyborski, 32, 33 Anup Ramachandran, 13 Vera Rogiers, 14 Cliff Rowe, 4 Celine Schelcher, 28 Kathrin Schmich, 11 Michael Schwarz, 23 Bijay Singh, 7 Ernst H. Nussler, 15 Peter Olinga, 12 Francesco Pampaloni, 22 Jingbo Pi, 35 Linda Pluta, 35 Stefan A. Maltman, 32 Madlen Matz-Soja, 21 Patrick McMullen, 35 Irmgard Merfort, 11 Simon Messner, 20 Christoph Meyer, 31 Jessica Mwinyi, 9 Dean J. LeCluyse, 35 Peng Lu, 35 Jennifer Luebke-Wheeler, 3 Anna Lutz, 11 Daniel J. Brian Houston, 34 Jens Hrach, 18 Kiyomi Ito, 16 Hartmut Jaeschke, 13 Verena Keitel, 6 Jens M. ![]() Groothuis, 46 Lena Gustavsson, 44 Christelle Guyot, 9 David Hallifax, 34 Seddik Hammad, 45 Adam Hayward, 33 Dieter Häussinger, 6 Claus Hellerbrand, 43 Philip Hewitt, 30 Stefan Hoehme, 26 Hermann-Georg Holzhütter, 42 J. Goldring, 4 María José Gómez-Lechón, 39, 40 Geny M. Craig Rowlands, 36 Uta Dahmen, 37 Georg Damm, 5 Olaf Dirsch, 38 María Teresa Donato, 39, 40, 41 Jian Dong, 35 Steven Dooley, 31 Dirk Drasdo, 26, 27, 49 Rowena Eakins, 4 Karine Sá Ferreira, 24, 25 Valentina Fonsato, 10 Joanna Fraczek, 14 Rolf Gebhardt, 21 Andrew Gibson, 4 Matthias Glanemann, 5 Chris E. Cameron, 8 Giovanni Camussi, 10 Chong-Su Cho, 7 Yun-Jaie Choi, 7 J. Budinsky, 36 Britta Burkhardt, 15 Neil R. Andersen, 35 Nariman Ansari, 22 Sudin Bhattacharya, 35 Johannes Georg Bode, 6 Jennifer Bolleyn, 14 Christoph Borner, 24 Jan Böttger, 21 Albert Braeuning, 23 Robert A. ![]()
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |